Follow a little boy and a penguin on their little adventure up in the mountain in search of something very special—Lonely Not. Along the way, they found smallness, eternity, freedom, tranquility, trust, waltz of the water, songs of the mountain and eventually, each other. This simple yet poetic picture-book features beautiful water-colour illustrations inspired by the idyllic landscapes of outskirt Wonju (원주), Korea where the author stayed for near to 3 months while on a residency.
The boy's heart there is a problem. The doctor says he is almost completely treated better, but the boy's aunt, was worried about his health, because only know aunt, the boy's heart, because they are aware of a terrible murder.
Since their discovery by Swiatoslaw Trofimenko in 1967, poly(pyrazol-1-yl)borates have been considered as one of the most useful ligands in modern coordination chemistry. The term “scorpionate” has been used to describe the interchange between bidentate and tridentate coordination modes by these ligands that has been employed for the synthesis of complexes with virtually every metal in the periodic table, having applications in diverse fields ranging from homogeneous catalysis to bioinorganic chemistry. This all-inclusive reference book continues where Trofimenko's original work left off. It not only includes discussions on all new ligands reported from 1999 to date, but also introduces ...
This resource continues where Trofimenko's original work left off. It not only includes discussions on all new ligands reported from 1999 to date, but also introduces new ligands, such as scorpionates based on S donors or P donors. As such, this volume is a 'must-have' for all researchers who use this family of molecules.
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.
The five-volume set LNCS 3980-3984 constitutes the refereed proceedings of the International Conference on Computational Science and Its Applications, ICCSA 2006. The volumes present a total of 664 papers organized according to the five major conference themes: computational methods, algorithms and applications high performance technical computing and networks advanced and emerging applications geometric modelling, graphics and visualization information systems and information technologies. This is Part I.
From the Introduction: Nanotechnology and its underpinning sciences are progressing with unprecedented rapidity. With technical advances in a variety of nanoscale fabrication and manipulation technologies, the whole topical area is maturing into a vibrant field that is generating new scientific research and a burgeoning range of commercial applications, with an annual market already at the trillion dollar threshold. The means of fabricating and controlling matter on the nanoscale afford striking and unprecedented opportunities to exploit a variety of exotic phenomena such as quantum, nanophotonic and nanoelectromechanical effects. Moreover, researchers are elucidating new perspectives on the...